Stavudine

By November 14, 2016Publications

Mahmoud Mirmehrabi et. al.
Acta Crystallographica, Section C: Crystal Structure Communications, C61(12), 695-698

Abstract

The crystal structure of the title compound (systematic name: 2′,3′-didehydro-2′,3′-deoxythymidine), C10H12N2O4, consists of two molecules in the asymmetric unit bound together by hydrogen bonds. The conformational geometry differentiates this form of stavudine from its two previously published polymorphs. In addition, a different hydrogen-bonding scheme is observed compared with the previous two structures. This polymorph is the thermodynamically most stable form of the antiviral drug, as evidenced by differential scanning calorimetry (DSC) and IR data.